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KMID : 1100720220420060621
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Annals of Laboratory Medicine
2022 Volume.42 No. 6 p.621 ~ p.629
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Age Group-specific Reference Intervals for the Elecsys Anti-Mullerian Hormone Assay in Healthy Korean Women: a Nationwide Population-based Study
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Ji Mi-Suk
Kim Kwang-Rae
Kim Hyun-Ki
Lee Woo-Chang
Yun Yeo-Min
Chun Sa-Il
Min Won-Ki
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Abstract
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Background: Anti-Mullerian hormone (AMH) is one of the most reliable markers of ovarian reserve. Automated AMH assays are widely used in clinical laboratories, but reference intervals for the Elecsys AMH assay for Asian populations have not yet been determined. We aimed to determine reference intervals in healthy Korean women.
Methods: The study included 1,450 women aged 19 to 54 years who participated in the Korea National Health and Nutrition Examination Survey between 2013 and 2016. The study participants were divided into seven 5-year age groups. AMH and progesterone concentrations were measured using Roche Elecsys assays, and bone morphogenetic protein-15 (BMP15) was genotyped for the detection of major variants. Age group-specific reference intervals for AMH were established as recommended by the CLSI EP28-A3c guidelines.
Results: The mean age was 37.4 years. AMH concentrations decreased with increasing age, especially after 40 years, with the median AMH decreasing from 30.9 pmol/L in participants of 19?24 years to 0.071 pmol/L in participants of 50?54 years. The mid-95 percentile AMH reference intervals decreased from 7.93?81.21 pmol/L in participants of 19?24 years to 0.07?3.86 pmol/L in participants of 50?54 years. Disease-associated BMP15 variants were not detected.
Conclusions: We determined Elecsys AMH assay reference intervals in healthy Korean women. The results may provide basic information for the interpretation of AMH concentrations and assessment of ovarian reserve in Korean women.
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KEYWORD
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Anti-Mullerian hormone, Reference intervals, Korean women, Immunoassay
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